内皮祖细胞对PCI术后内皮损伤的修复作用研究进展

The Repair Function of Endothelial Progenitor Cells of Endothelial Injury in Patients after PCI

经皮冠状动脉介入治疗(PCI)是治疗冠心病的重要手段。然而PCI会导致机械性血管损伤,进一步导致冠状动脉血管再狭窄和支架内急性血栓事件。研究发现内皮祖细胞(EPC)在动脉粥样硬化病变发展过程中可能起着重要作用,现就EPC的作用特点、机制、预测机制和治疗作用等方面阐述EPC对PCI术后冠心病患者内皮损伤的修复作用。

Percutaneous coronary intervention( PCI) is one of the important means of treatment of coronary heart disease,early PCI treatment can restore a stable coronary blood flow,reduce infarct size,thereby improve prognosis and reduce case fatality rate. However PCI causes mechanical vascular injury,the Stent and Balloon dilatation causes endothelial denudation,intimal tear,activate the excessive proliferation of smooth muscle cells and platelet adhesion and aggregation,leading to stenosis and thrombosis. Drug-eluting stent Restenosis was reduced to a certain extent,but could cause to delay endothelialization and lead to late stent thrombosis formation. Bone marrow and peripheral blood endothelial progenitor cells( EPC) involvement of endothelial and angiogenesis,in atherosclerotic lesions may play an important role in the development process,this paper discusses the role,characteristics,mechanism and prediction mechanism and therapeutic aspects of EPC to the repair function of endothelial injury in patients with CHD after PCI.