NSTEACS患者高敏C反应蛋白、血清高迁移率族蛋白1和细胞间黏附分子1与GRACE评分的相关性

Relationship Between High-sensitivity C-reactive Protein,High Mobility Group Box-1 Protein and Intercellular Adhesion Molecule-1 with GRACE Score in NSTEACS Patients

目的通过观察非ST段抬高型急性冠状动脉综合征(NSTEACS)患者高敏C反应蛋白、血清高迁移率族蛋白1、细胞间黏附分子1与GRACE评分之间的关系,评价高敏C反应蛋白、血清高迁移率族蛋白1以及细胞间黏附分子1在评估NSTEACS患者危险程度中的应用价值。方法随机选择NSTEACS患者进行GRACE评分,评分≤108分为低危组,109~140分为中危组,>140分为高危组;随机选择冠状动脉造影阴性志愿者为对照组。检测各组血清中高敏C反应蛋白、血清高迁移率族蛋白1、细胞间黏附分子1的浓度,比较高、中、低危组与对照组中各指标的差异,同时分析各项指标与GRACE评分之间的相关性。结果低危组、中危组、高危组及对照组之间高敏C反应蛋白、血清高迁移率族蛋白1、细胞间黏附分子1浓度两两相比都有显著性差异;相关分析发现高敏C反应蛋白、血清高迁移率族蛋白1、细胞间黏附分子1浓度与GRACE评分之间存在显著正相关(r分别为0.498、0.561、0.526)。结论非ST段抬高型急性冠状动脉综合征患者高敏C反应蛋白、血清高迁移率族蛋白1、细胞间黏附分子1与GRACE评分有密切关系,高敏C反应蛋白、血清高迁移率族蛋白1、细胞间黏附分子1在评估NSTEACS患者危险程度中有一定的应用价值。

Aim To observe relationship between high-sensitivity C-reactive protein( hs-CRP),high mobility group box-1 protein( HMGB1) and intercellular adhesion molecule-1( ICAM1) with GRACE score,and to clarify the value of hs-CRP,HMGB1 and ICAM1 in estimating the criticality of non-ST segment elevation acute coronary syndrome( NSTEACS) patients. Methods According to the GRACE score NSTEACS patients were divided into different groups: risk group( ≤108 scores),middle risk group( 109 ~ 140 scores),high risk group( > 140 scores),and 20 volunteers negative in coronary angiography( CAG) were as the control group. The levels of hs-CRP,HMGB1,ICAM1 in each group were detected,and the indexes were compared among various groups. Relationship between the indexes and GRACE score was analyzed. Results The levels of hs-CRP,HMGB1,ICAM1 in four groups were significantly different from each other. At the same time,hs-CRP,HMGB1,ICAM1 have significantly positive relationship with GRACE score( r = 0. 498,0. 561,0. 526). Conclusion hs-CRP,HMGB1,ICAM1 have intimate connection with GRACE score,and have practical value in estimating the criticality of NSTEACS patients.