中老年人群血尿酸水平与颈动脉斑块的相关性

The Relationship Between the Level of Uric Acid and Carotid Plaques in Middle-aged and Elderly Populations

目的分析中老年人群不同血尿酸水平对颈动脉斑块的影响。方法随机分层抽取唐山开滦(集团)有限责任公司在职及离退休职工中年龄≥40岁、既往无脑卒中、短暂性脑缺血发作、心肌梗死者共5298例为调查对象,进行统一问卷调查、血液生化及颈动脉超声检测,采用Logistic回归分析不同血尿酸水平对是否发生颈动脉斑块的影响。结果 1共有5298例纳入统计分析,其中男性3180例,女性2118例,年龄41~95(56.3±11.7)岁;2分性别按血尿酸四分位进行分组后,随着血尿酸水平的增高,男性及女性研究人群的年龄、体质指数、总胆固醇、甘油三酯水平升高,高密度脂蛋白胆固醇水平降低,组间比较差异有统计学意义(P<0.05);3男性不同尿酸水平组斑块检出率分别为42.52%、50.89%、55.04%和56.43%;女性分别为20.69%、21.51%、25.71%和35.94%,组间比较差异有统计学意义(P<0.05);4单因素Logistic回归分析显示在男性人群中,以尿酸<246.05μmol/L为对照组,246.05μmol/L≤尿酸<305μmol/L组、305μmol/L≤尿酸<371μmol/L组和尿酸≥371μmol/L组发生颈动脉斑块的OR(95%CI)分别为1.44(1.18~1.76)、1.71(1.4~2.09)和1.8(1.47~2.2);女性人群中,以尿酸<202μmol/L为对照组,202μmol/L≤尿酸<244μmol/L组、244μmol/L≤尿酸<294μmol/L组和尿酸≥294μmol/L组发生颈动脉斑块的OR(95%CI)分别为1.03(0.76~1.39)、1.32(0.98~1.76)和2.1(1.59~2.77)(均P<0.05)。5多因素Logistic回归分析显示校正了不同混杂因素后,在不同性别人群中,尿酸不是影响颈动脉斑块的独立危险因素(P>0.05)。结论中老年人群血尿酸水平不是发生颈动脉斑块的独立危险因素。

Aim To explore the relationship between the level of uric acid and carotid plaques. Methods From June 2010 to June 2011,a total of 5298 workers of Tangshan Kailuan Group who were aged 40 and over was selected by randomly receiving the surveys,including unified questionnaire,blood biochemistry measurement,and brachial-ankle pulse wave velocity detection,and the workers were without cerebral apoplexy,transient ischemic attack,and myocardial infarction,multivariate logistic regression analysis was used to analyze the relationship between the level of uric acid and carotid plaques. Results 1A total of 5298 eligible participants was enrolled,including 3180 males and 2118 females at an average age of( 56. 3 ± 11. 7) years old( from 41 to 95 years old). 2The age,body mass index( BMI),total cholesterol and triglyceride of the high level uric acid group were significantly higher than those of low level uric acid group in both males and females. 3 Occurrence rate of carotid plaques was respectively 20. 69%,21. 51%,25. 71% and35. 94% in uric acid groups of different level. 4Single logistic regression analysis showed that compared with the uric acid < 246. 05 μmol / L group,the OR( 95% CI) was 1. 44( 1. 18 ~ 1. 76),1. 71( 1. 4 ~ 2. 09) and 1. 8( 1. 47 ~ 2. 2)respectively in 246. 05 μmol / L≤uric acid < 305 μmol / L group,305 μmol / L≤ uric acid < 371 μmol / L group and uric acid≥371 μmol / L group in men. Compared with the uric acid < 202 μmol / L group,the OR( 95% CI) was 1. 03( 0. 76 ~1. 39),1. 32( 0. 98 ~ 1. 76) and 2. 1( 1. 59 ~ 2. 77) respectively in 202 μmol / L≤uric acid < 244 μmol / L group,244μmol /L≤uric acid < 294 μmol /L group and uric acid≥294 μmol /L group in women( P < 0. 05). 5The uric acid was not the risk factor of carotid artery plaques( P > 0. 05). Conclusion The level of uric acid is not an independent risk factor for carotid plaques.