反社会人格障碍患者的脑结构磁共振分析

Brain structure analysis for patients with antisocial personality disorder by MRI

目的:研究无酗酒、吸毒和其他并发症的反社会人格障碍(antisocial personality disorder,ASPD)患者的脑结构异常征象。方法:选择36名ASPD患者和26名健康对照者行T1结构磁共振成像和扩散张量成像(diffusion tensor imaging,DTI),计算得到每个对象基于体素的形态学图和各向异性分数(fractional anisotropy,FA)图。结果:与健康对照者相比,ASPD患者顶下小叶有明显的灰质体积增大(P≤0.001),楔前叶白质体积增多(P≤0.001),左扣带回、双侧的楔前叶、右额上回和右颞中回FA值增大(P≤0.01)。结论:ASPD存在脑结构上的异常,ASPD外在的行为特征可能与这些脑区的异常有关。

Objective: To investigate the structural abnormalities of brain in patients with antisocial personality disorder(ASPD) but without alcoholism and drug abuse. Methods: Volunteers from Hunan Reformatory(n=36) and the matched healthy subjects(n=26) were examined by high-spatial resolution magnetic resonance imaging(MRI) and diff usion tensor imaging(DTI). Voxel-based morphometry and fractional anisotropy(FA) maps were generated for each subject to reveal structural abnormalities in patients with ASPD. Results: Compared with the healthy controls, ASPD patients showed significantly higher gray matt er volumes in the inferior parietal lobule(P≤0.001, uncorrected), white matt er volumes in the precuneus(P≤0.001, uncorrected), FA in the left lingual gyrus, bilateral precuneus, right superior frontal gyrus and right middle temporal gyrus(P≤0.01, uncorrected). Conclusion: Our results revealed the abnormal neuroanatomical features in ASPD patients, which might be related to the external behavioral traits in ASPD patients.