Toll样受体与非可控性炎症相关肿瘤

Toll-like receptors and non-resolving inflammationrelated cancer

Toll样受体(Toll-like receptors,TLRs)是一类单一的、非催化的、具有较高同源性的模式识别受体,在天然免疫中发挥了重要作用,是连接天然免疫和特异性免疫的桥梁。Toll样受体在非可控性炎症相关肿瘤中的炎症微环境形成、免疫逃逸、侵袭和转移等方面均发挥了重要作用。深入研究Toll样受体在非可控性炎症相关肿瘤中的作用机制,可以为肿瘤的预防、早期诊断及治疗提供新的方向。

Toll-like receptors(TLRs) is a type of patt ern recognition receptors(PRRs), which are singular, non-catalytic and highly homologous. TLRs not only play significant roles in natural immunity, but also act as a bridge between innate immunity and adaptive immunity. Recent studies have revealed that TLRs play critical roles in the development of non-resolving inflammation-related cancer, including the formation of tumor microenvironment, invasion and metastasis, immune escape, etc. Further investigation into the mechanisms responsible for the function of TLRs will be of great value in tumor prevention, early diagnosis and therapy.