RASAL2在肝细胞癌中的表达及临床意义

Expression of RASAL2 in hepatocellular carcinoma and the clinical significance

目的:检测肝细胞癌患者癌组织与癌旁组织中RA SAL2蛋白的表达,探讨RA SAL2与临床病理特征及预后的关系。方法:用免疫组织化学SP法检测164对癌组织与癌旁组织中RASAL2的表达,分析RASAL2的表达与临床病理特征及预后的关系。结果:RASAL2在肝细胞癌旁组织中的表达比癌组织高(P<0.001);RASAL2的表达同肿瘤的分化程度、TNM分期及有无血管侵犯有关(均P<0.001),与AFP水平、肿块大小及结节数目等无关(P>0.05);RA SAL2低表达患者的5年无复发生存期(recurrence-free survival,RFS)(P<0.001)和总生存期(overall survival,OS)(P<0.001)明显低于RA SAL2高表达的患者。Cox回归分析显示RASAL2低表达是肝癌患者术后复发和死亡的独立因素(P<0.001)。结论:RASAL2的低表达与肝细胞癌的不良预后显著相关,是其不良预后的独立因素。

Objective: To detect the expression of RA SAL2 in patients with hepatocellular carcinoma(HCC), and to investigate the association of RASAL2 expression with pathological characteristics and prognosis.Methods: Immunohistochemical SP method was used to detect the expression of RA SAL2 in 164 samples of HCC tissue and the adjacent tissue. The association of RA SAL2 expression with clinical features and prognosis was analyzed.Results: The expression of RASAL2 in adjacent tissue was significantly increased compared to that in HCC tissue(P<0.001). The expression level of RASAL2 was associated with the degree of dif ferentiation, tumor TNM stage and vascular invasion(P<0.001), but not associated with the level of AFP, tumor size, or the number of nodules(P>0.05). The 5 years recurrence-free survival(RFS) in patients with low expression of RASLA2 was significantly reduced compared with that in patients with high expression of RASLA2(P<0.001). Cox analysis showed that low expression of RASLA2 was the independent factor for recurrence and death in HCC patients after surgery(P<0.001).Conclusion: Low expression of RRASAL2 is significantly associated with the poor prognosis of HCC, which is an independent factor for HCC prognosis.