月桂醇基海藻酸钠与层状双金属纳米颗粒稳定载药Pickering乳液及其缓释性能

Drug-Controlled Release Properties of Stable Pickering Emulsion Prepared with Dodecanol Algiante and Layer Double Hydroxide Nanoparticles

为了提高海藻酸钠(SA)对疏水性农药的负载量和释药缓释作用,将其与月桂醇通过偶联酯化反应进行疏水改性,对改性后的海藻酸钠进行红外光谱、核磁共振表征分析,结果证明月桂醇侧链成功接枝到海藻酸钠分子骨架上。将月桂醇改性海藻酸钠(DA)和十六烷基三甲基溴化铵(CTAB)与层状双金属氢氧化物(LDH)纳米颗粒进行复配,其Zeta电位分别为+44.9 m V和-33.2 m V,同时其粒径分别增大到93.3 nm和659.8 nm。结果表明带负电的月桂醇改性海藻酸钠吸附在层状双金属氢氧化物颗粒表面可以阻碍颗粒间的相互聚集,在分散体系中表现出了良好的稳定性能。高速剪切下制备稳定Pickering乳液,对疏水性农药氯氟氰菊酯进行了释药试验,表明改性后的海藻酸钠与LDH颗粒制备Pickering乳液对氯氟氰菊酯具有较好的药物缓释作用。

In order to increase the loading dose of hydrophobic drugs on alginate and control the drug release,dodecanol was covalently coupled to sodium alginate via ester functions using a coupling reagent to provide an amphiphilic dodecanol alginate( DA) for subsequent use in oil-in-water Pickering emulsion loaded cyhalothrin application. The structure of dodecanol alginate was confirmed by FT-IR,1H-NMR spectrometry. The results prove that dodecanol side chain was successfully grafted onto the molecular skeleton of sodium alginate. And the modified sodium alginate and hexadecyltrimethylammonium bromide( CTAB) with layer double hydroxide( LDH) nanoparticles for mixture respectively,the zeta potential is + 44. 9 m V and- 33. 2 m V respectively,at the same time,the particle size increases to 93. 3 nm and659. 8 nm. The results show that negatively charged dodecanol alginate adsorption on the surface of LDH particles can block the mutual coalescence effect between particles,in the Pickering emulsions show good stability. The drug-loaded Pickering emulsion is prepared under high-speed shearing condition. The results indicate that dodecanol alginate and LDH nanoparticles stabilized Pickering emulsion present better drug-controlled release effect.