对称双-1,3,4-噁二唑化合物的合成及性质

Syntheses and Properties of Symmetric Bis-1,3,4-oxadiazoles

首先以苯氧乙酰肼和二酰氯为原料反应得到对称双酰肼化合物,再以POCl3合环得到系列对称双-1,3,4-噁二唑化合物。考察了该系列化合物的紫外-可见吸收光谱,其中,间苯双-1,3,4-噁二唑化合物在250nm附近有明显的最大吸收峰,对苯双-1,3,4-噁二唑化合物的最大吸收峰则红移至290nm附近;而脂肪族双-1,3,4-噁二唑化合物没有明显的最大吸收峰,说明没有大的共轭体系,与结构相符合。所有化合物的结构均经元素分析、IR、1H NMR和MS确证。

First of all,phenoxyacetic acid hydrazide and di-acyl chloride are used to synthesize dihydrazide compounds,then a series of symmetric bis-1,3,4-oxadiazoles were synthesized by cyclization with phosphorus oxychloride,and their UV-Vis absorption were studied. UV-Vis maximum absorption peak of m-benzene bis-1,3,4-oxadiazole is located at about 250 nm,that of p-benzene bis-1,3,4-oxadiazole shows an obvious red shift,located at about 290 nm. Alkanoic bis-1,3,4-oxadiazole did not appear any maximum absorption peak,showing there is no conjugated system in molecule,which is consistent with the its molecular structure. The structure of these compounds were confirmed by elemental analysis,IR,1H NMR and MS.