粤东地区结直肠癌患者的临床病理特征及预后分析

Analysis of clinicopathologic features and prognosis of colorectal cancer patients in Eastern Guangdong area

目的探讨粤东地区结直肠癌患者的临床病理特征及其对预后的影响。方法回顾性分析2008至2012年汕头大学医学院第一附属医院胃肠外科收治的315例结直肠癌患者的临床病理资料及随访资料,分析临床病理与预后的关系。结果本组结直肠癌患者3年生存率及5年生存率分别为70%、62%。单因素分析显示年龄、TNM分期、T分期、N分期及M分期是患者预后的影响因素;多因素分析显示年龄、TNM分期、N分期及M分期是结直肠癌的独立预后因素。结论粤东地区结直肠癌患者年龄、TNM分期、N分期及M分期是独立预后因素,分析病理资料的地区特点及预后,有助于指导该地区结直肠癌的预防和治疗。

Objective To investigate the clinicopathological features and prognosis of colorectal cancer patients in the eastern region of Guangdong. Methods From 2008 to 2012, clinical data and prognosis of colorectal cancer patients which received surgical treatment in the First Affiliated Hospital,Medical College of Shantou University were analyzed retrospectively. The regional characteristics of clinicopathology and prognosis were generalized and analyzed. Results The 3- and 5-year survival rates of colorectal cancer patients in the eastern region of Guangdong were 70%, 62% respectively. Univariate analysis revealed that age, TNM, T, N and M stages were prognostic factors, while multi-factor analysis revealed that age,TNM,N and M stages were independent prognostic factors for colorectal cancer in the eastern region of Guangdong. Conclusions Age,TNM,N and M stages were independent prognostic factors for colorectal cancer in the eastern region of Guangdong. Generalization and analysis of regional characteristics of clinicopathology and prognosis in different regions are helpful to guide the prevention and treatment of colorectal cancer.