血管紧张素转化酶基因多态性与腹主动脉瘤易感性关系的Meta分析

The association between angiotensin Ⅰ converting enzyme polymorphism and abdominal aortic aneurysm susceptibility:a meta-analysis

目的探讨血管紧张素转化酶(ACE)基因多态性与腹主动脉瘤(AAA)的相关性。方法检索截止至2015年12月发表各数据库评价ACE基因多态性与AAA关系的研究进行Meta分析。结果共有10篇文献满足纳入标准,共6845例纳入研究,其中AAA患者3226例,健康对照3619例。隐性基因模型比值比(OR)=1.21(95%CI=0.94~1.55,P=0.13),等位基因模型OR=1.20(95%CI=1.01~1.41,P=0.03),显性基因模型OR=1.31(95%CI=1.05~1.63,P=0.02)。敏感性分析根据吸烟、高血压及血脂紊乱三项对各个统计资料进行评估,6篇文献符合条件,隐性基因模型OR=1.43(95%CI=1.04~1.98,P=0.03),等位基因模型OR=1.20(95%CI=1.01~1.41,P=0.03),显性基因模型OR=1.35(95%CI=1.06~1.73,P=0.02)。结论相比于等位I基因,D等位基因个体可能具有更高的AAA易感性,但由于现有标本量及种族差异的限制,需用广泛大样本统计得以完善。

Objective To evaluate the association between angiotensin I converting enzyme(ACE)polymorphism and abdominal aortic aneurysm(AAA) susceptibility.Method The literatures about the association between ACE polymorphism and AAA were collected by searching related database until December 2015.Then a meta-analysis was performed by using of fixed or random effects model.Result A total of 10 references met inclusion criteria,and 3226 AAA patients and 3619 healthy controls were included in this study.Recessive model odds ratio(OR)=1.21(95%CI=0.94~1.55,P =0.13),Allele model OR =1.20(95% CI =1.01 ~1.41,P =0.03),Dominant model OR =1.31(95% CI =1.05 ~1.63,P =0.02).Sensitivity analysis on the side of smoking,hypertension and dyslipidemia revealed a pooled OR value 1.43(95% CI =1.04 ~1.98,P =0.03) in recessive model,1.20(95% CI =1.01 ~1.41,P =0.03) in allele model and1.35(95% CI =1.06 ~1.73,P =0.02) in dominant model.Conclusion Compared to I alleles,an individual who carries D alleles is more susceptible to AAA.The result needs to be verified by large sample studies for the limitation of sample size and radical difference in current meta-analysis.