骨保合剂对去势模型大鼠骨密度影响的研究

Effect of Gubao mixture on the bone mineral density of ovariectomized rats

目的:探讨骨保合剂对去势模型大鼠骨密度的影响。方法:6月龄雌性Wistar大鼠40只,随机分为空白对照组、模型组、骨康组和骨保组,每组10只,骨保组给予骨保合剂;骨康组给予骨康胶囊;空白对照组及模型组均以等量生理盐水灌胃。用双能X线骨密度测量仪测量大鼠骨密度值。结果:骨保组与骨康组骨密度(g/cm2)明显高于模型组(分别为:0.145±0.007,0.145±0.007,0.137±0.006;t=3.00,2.80,P<0.05),且与空白对照组(0.148±0.014)无显著差异(t=1.00,1.09,P>0.05)。骨保组与骨康组比较亦无显著性差异(t=0.17,P>0.05)。结论:骨宝合剂可提高骨密度,防治绝经后骨质疏松症。

AIM:To explore the effect of Gubao mixture on ovariectomized rats' bone mass d ensity(BMD). METHODS:Forty female Wistar rats,aged 6 months old,were randomly divided into 4 groups of 10 each:Gubao group(treated with Gubao mixture),Gukang group(treated with Gukang capsule),blank control group and model group,and rats in the latter two groups were treated with saline of the same volume by intragastric infusion .BMD was detected by double energy X-ray BMD instrument. RESULTS:BMDs(g/cm2) in the Gubao group(0.145±0.007) and Gukang group(0.145±0 .007) were obviously higher than that in the model group(0.137±0.006)(t=3.00, 2 .80,P< 0.05),and not significantly different from that in the blank control grou p (0.148±0.014)(t=1.00,1.09,P >0.05).There was no significant difference in BMD between the Gubao group and Gukang group(t=0.17,P >0.05). CONCLUSION:Gubao mixture can upgrade BMD to prevent and cure postmenopausal os teoporosis.