成人重症肌无力胸腺切除术后远期生活质量评价

Long-term quality of life of adult patients with myasthenia gravis after thymectomy

目的 探讨胸腺切除术对成人重症肌无力患者生活质量的影响。方法 采用调整后的欧洲癌症研究与治疗组织QLQ C3 0量表 ,评价 10 2例胸腺切除满 3年的成人重症肌无力患者及 3 2例术前成人重症肌无力患者的生活质量 ,应用Mann Whitney方法比较两组患者的生活质量。结果 MG远期手术组患者的体力功能、角色功能、社会功能、总生活质量维度较术前组有显著改善 ,情感功能改善不显著。MG远期手术组患者需要休息、虚弱、力量下降较术前组显著改善 ,经济困难加重。结论 重症肌无力成人患者胸腺切除后远期生活质量提高显著 ,但仍未完全恢复正常 ,角色功能、情感功能障碍。

Objective To evaluate the long term quality of life of adult patients with myasthenia gravis after thymectomy. Methods Quality of life of 102 adult patients with myasthenia gravis at more than 3 years after thymectomy and 32 patients with myasthenia gravis before operation was evaluated using the Modified European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) C30. The quality of life of patients in the two groups was compared using Mann Whitney method. Results The scores of physical function, working ability, social function, and global quality of life in the thymectomy group were higher than those in the control group (preoperative group). No significant difference in emotional function was found between the two groups. Scores of need for rest, weakness, and physical power decrease were lower in the thymectomy group than those in the control group, but the score of economic burden was greater than that in the control group. Conclusion The long term quality of life of adult patients with myasthenia gravis treated with thymectomy is better than that of the patients without operation, but the complete recovery of normal life can not be achieved. More attention should be paid to working ability, emotional function, and economic burden to improve the long term quality of life of adult patients with myasthenia gravis after thymectomy.