重症肝炎并发急性低钠综合征26例临床分析

Severe hepatitis complicated hyponatimia syndrome: clinical analysis of 26 cases

目的 探讨重症肝炎并发急性低钠综合征的原因。方法 对我院2001至2002年26例重症肝炎并发急性低钠综合征患者的临床分级、临床表现、诱发因素、治疗及转归等资料进行临床分析。结果 26例患者中急性低钠综合征轻度、中度、重度分别为16例(62%)、7例(27%)、3例(11%)。临床表现以恶心、乏力、呕吐为主。大量利尿是主要诱因。补钠治疗后14例好转(54%),12例死亡(46%)。结论 重症肝炎并发急性低钠综合征死亡率高,须及早发现,积极治疗。原因考虑是多种因素造成。

Object To investigate the pathophysiology of severe hepatitis complicated hyponatimiasyndrome.Methods To analyze 26 cases with the severe hepatitis hyponatimia in our hospital from year2001 to 2002 by Patient's clinical rating, clinical presentations, predisposing factors, treatment, andprognoses.Results In the selected cohort, mild 16 cases(62%), moderate 7 cases (27%), severe 3 cases(11%). Disgusted, tired, and vomit are the main clinical presentations. Overdiurese is the leading cause,mechanism of 14 cases responded to Na+ replenish therapy, while 12 died. Conclusion Severe hepatitiscomplicated hyponatrimia syndrome mortality rate is high. Early diagnosis and prompt and propertreatment are crucial for prognoses. Multiple factors may contribute to the formation of the presentedsyndrome and further research is highly recommended to in this area.