胸腔内联合注入生物反应调节剂治疗恶性胸腔积液疗效对比

Treatment of malignant pleural effusion using Pseudmonas Vacine injection and Thrombin intrapleurally injection

目的 探讨胸腔内注入佳代胞联合凝血酶治疗恶性胸腔积液的疗效。方法 病理确诊恶性胸腔积液60例,经皮穿刺胸腔内置中心静脉导管持续引流排尽胸腔积液后,按随机化原则分为2组。治疗组在胸腔内注入佳代胞4ml,凝血酶2000u,对照组(28例)胸腔内注入凝血酶2000u,4周后观察两组的疗效及毒副作用。 结果 治疗组总有效率84%,较对照组54%,差异有显著性(p<0.05)。 结论 胸腔内联合注入佳代胞和凝血酶是一种有效的、副反应小、可耐受的方法。

Objective To evaluate efficacy of treating malignant pleural effusion with PseudmonasVacine injection and Thrombin by injection through tube intubation.Methods 50cases with malignantpleural effusion, after drainage, Pseudmonas Vacine injection 4ml,Thrombin 2000u were injected intopleural cavity in therapy group(T),and only Thrombin 2000u in control group(C).after 4 weeks evaluatethe efficacy and toxicities. Rsults The response rate was 81% in T group and 54% in C group .There wasstatistical difference in two groups(P<0.05). Conclusion The treatment to use Pseudmonas Vacineinjection and Thrombin through thoracic tube is regarded as effective ,slight side-effect and welltoleratedmethod for malignant pleural effusion.