微粒子酶免疫法检测血清β-HCG在妊娠相关疾病鉴别诊断中的临床意义

Study on Clinical Significance of Serum β-HCG Determined with MEIA in Pregnancy Associated Diseases

目的 探讨微粒子酶免疫法(MEIA法)检测血清β-HCG在异位妊娠和滋养细胞疾病诊断中的临床应用价值。方法 应用MEIA法检测36例异位妊娠患者,35例滋养细胞疾病患者(包括葡萄胎患者23例,绒毛膜癌患者12例),28例非妊娠所致急腹症患者及52例正常早孕患者血清β-HCG水平,并与正常未孕妇女组比较。结果 异位妊娠组血清β-HCG明显低于正常早孕组;与正常未孕组和非妊娠急腹症组之间比较,差异也有显著性意义(P<0.01)。滋养细胞疾病组血清β-HCG则明显高于其余各组,差异有显著性意义(P<0.01)。结论 MEIA法测定血清β-HCG具有快速、准确的特点,对妊娠相关疾病的早期诊断和鉴别诊断具有重要意义。

Objective To study the clinical significance of serum β-HCG determined withmicropartical enzyme immunoassay(MEIA) in pregnancy associated diseases. Methods In this study, fourgroups: 71 patients with abnormal pregnancy, 28 patients with surgical abdomen, 52 normal pregnancypatients and 40 healthy females were included. The concentration ofβ-HCG in serum was determined.Results In ectopic pregnancy group, the concentration ofβ-HCG was significantly lower than that inthe normal pregnancy group, while was higher than that in the healthy and surgical abdomen ones. Introphocyte disease groups, the level of β-HCG was significantly higher than other ones. ConclusionThe MEIA method is rapid and precise to perform. The assay has an important value on the diagnosis ofpregnancy associated diseases.