前列腺素E_1治疗不稳定性心绞痛30例临床观察

Clinical observation of the effcts of PGE_1 on 30 cases with unstable angina pectoris

目的 观察前列腺素E1(PGE1)治疗不稳定性心绞痛 (UA)的疗效及安全性。方法 对 30例UA病人使用PGE1180 μg/d治疗 ,15d为 1个疗程。对照组使用杏丁注射液 2 0ml/d治疗 ,15d为 1个疗程。观察两组病人心绞痛缓解情况及心电图、超声心动图、血脂等治疗前后的变化并进行统计分析。结果 PGE1缓解心绞痛总有效率为 80 % ,其结果优于对照组 ,差异有显著意义 (P <0 0 1) ,且病人左室功能得到改善 ,血脂亦明显下降 ,治疗前后对比差异有显著意义 (P <0 0 1)。结论 PGE1可有效治疗UA。

Objective To observe the effects of PGE 1 on unstable angina pectoris.Methods 30 cases with unstable angina pectoris accepted PGE 1 treatment(180μg/d) for 15 days.Another 30 cases as contrast group accepted Xingding injection treatment(20ml/d) for 15 days.The relief of angina pectoris and the changes of ECG,UCG and serum lipid level before and after treatment in the two groups.Results The effective rates of PGE 1 for unstable angina pectoris was 80%,and was higher than that of contrast group significantly(P<0.01).The improvement in left ventricular function and the decline of blood plasma lipid level were significant after treatment(P<0.01).Conclusion PGE 1 is an effective drug for unstable angina pectoris.