健脾消痞浸膏对脾虚大鼠胃分泌影响的实验研究

Effects of Jianpi Xiaopi extract on gastric secretion of spleen deficiency rats

目的 观察健脾消痞浸膏对脾虚大鼠胃分泌的影响。方法 用大黄水煎剂造脾虚动物模型 ,用滴定法测定胃液分泌 ,用放射免疫法测定血浆胃泌素。结果 与脾虚模型组比较 ,健脾消痞浸膏中剂量组总酸度、总酸排出量升高 (P<0 .0 5 ) ,高剂量组胃液量、总酸度、总酸排出量均显著升高 (P <0 .0 1)。中、高剂量组血浆胃泌素显著升高 (P <0 .0 1)。

Objective To observe the effects of Jianpi Xiaopi extract on gastric secretion of experimental SD rats with spleen deficiency. Methods Animal model of spleen deficiency was established by using Rhubarb decoction. The gastric secretion was determined by titration method, and the gastrin in plasma was measured by radioimmunoassay. Results Compared with those in spleen deficiency group, the levels of the total acidity and the output of total acid were higher in the middle dose group treated with Jianpi Xiaopi extract ( P <0.05). The levels of the gastric juice, total acidity, and output of total acid were significantly higher in the high dose group ( P <0.01). The gastrin in plasma was significantly higher in the middle and high dose groups treated with Jianpi Xiaopi extract ( P <0 01). Conclusion Jianpi Xiaopi extract can stimulate gastric secretion and increase gastrin in plasma of rats with spleen deficiency.