肝星形细胞激活的转录调节
Transcriptional regulation of hepatic stellate cells
摘要
肝星形细胞(HSC)被认为是肝纤维化的关键成分,因此了解启动和持续HSC激活的分子机制有重 要意义。基因转录水平的HSC激活需要同时激活几种HSC基因组的关键转录调节者。现综述调节激活HSC的几 种转录因子。
参考文献18
-
1Friedman SL. The cellular basis of hepatic fibrosis. N Engl J Med, 1993,328(25): 1828-1835.
-
2Lemmon B, Tijan R. Orchestrated response: a symphony of transcription factors for gene control. Genes Dev,2000,14:2551-2569.
-
3Desterro JM, Rodriguez MS, Hay RT. Regulation of transcription factors by protein degradation. Cell Mol Life Sci,2000,57(8-9): 1207-1219.
-
4Elsharkawy AM, Wright MC, Hay RT.et al. Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of lkappaB family proteins. Hepatology, 1999, 30(3): 761-769.
-
5Gallois C, Habib A, Tao J,et al. Role of NF-kappa B in the antiproliferative effect of endothelin-1 and tumor necrosis factor-alpha in human hepatic stellate cells. Involvement of cyclooxygenase-2. J Biol Chem, 1998,273 (36) :23183-23190.
-
6Turner J, Crossley M. Basic Kruppeel-like factor functions within a netork of interacting haematopoietic transcription factors. Int J Biochem Cell Biol, 1999,31(10): 1169-1174.
-
7Chen A, Davis BH. The DNA binding protein BTEB mediates acetaldehyde-induced, jun N-terminal kinaae-dependent alphal(l) collagen gene expression in rat hepatic stellate cells. Mol Cell Biol,2000,20(8):2818-2826.
-
8Rippe RA, Almounajed G, Brenner DA. Spl binding activity increases in activated Ito cells. Hepatology, 1995,22( 1 ) :241 -251.
-
9Ratziu V, Lalazar A, Wong L, et al. Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. Proc Nail Acad Sci USA, 1998,95(16) :9500-9505.
-
10Rippe RA, Schrum LW, Stefanovic B, et al. NF-kappaB inhibits expression of the alphal (I) collagen gene. DNA Cell Biol,1999,18(10):751-761.
-
1申友奎,杨勇,董礼文,楼正清,王军,傅晓青.KLF2预测内毒素所致大鼠急性肺损伤的观察[J].浙江临床医学,2014,16(11):1696-1698.
-
2张帅帅,徐燕,邓书会,秦宇,杜晨星,毛雪涵,邱录贵.miRl37及其靶基因Kruppel样转录因子12在多发性骨髓瘤中的表达及预后意义[J].白血病．淋巴瘤,2016,25(6):326-329. 被引量：1
-
3易萍,程明亮.针对肝星状细胞抗肝纤维化治疗的研究进展[J].西部医学,2009,21(1):133-134. 被引量：2
-
4齐晓艳,陈新华.转化生长因子β与肝纤维化的研究[J].临床肝胆病杂志,2010,26(2):223-224. 被引量：3
-
5姚冬.γ-干扰素抗肝纤维化的实验与临床研究[J].天津药学,2001,13(3):13-14. 被引量：2
-
6张银凤,金仲品.糖脂质代谢及胰岛素抵抗的转录调节[J].医学综述,2002,8(11):660-661.
-
7陆建华,李茂岚,江林,吴向嵩,吴文广,董平,顾钧,毕建威.小干扰RNA沉默Kruppel样转录因子8对胃癌细胞增殖及侵袭能力的影响[J].中华实验外科杂志,2015,32(2):316-318. 被引量：3
-
8姜志胜,董林旺,杨军,佟利家,庞永政,唐朝枢,刘乃奎.脓毒血症大鼠心肌II型磷脂酶A_2活性变化及其调控[J].生物化学与生物物理学报,1999,31(4):373-378.
-
9李良刚.Ⅱ型组蛋白去乙酰化酶可能参与收缩骨骼肌葡萄糖转运蛋白4基因表达的转录调节[J].中国运动医学杂志,2007,26(6):763-766. 被引量：3
-
10HOU Wei-kai,XIAN Yu-xin,ZHANG Li,LAI Hong,HOU Xin-guo,XU Yu-xin,YU Ting,XU Fu-yu,FU Chun-li,ZHANG Wen-wen,CHEN Li.Influence of blood glucose on the expression of glucose transporter proteins 1 and 3 in the brain of diabetic rats[J].Chinese Medical Journal,2007(19):1704-1709. 被引量：8
