从生物力学角度探讨XW630对实验性骨折愈合的影响

A Biomechanical Evaluation of the Effects of XW630 on the Healing of Experimental Fracture

探讨四环素雌酚酮（ＸＷ６３０）是否对实验性骨折愈合具有促进作用。在１２０只新西兰大白兔实验性桡骨骨折愈合过程中给予ＸＷ６３０、雌酚酮（Ｅ２）、四环素（Ｔ）和生理盐水（对照组Ｃ）治疗；采用肌肉注射与伤口局部两种给药方式。测定了骨折术后３０天、６０天和９０天愈合骨的弯曲和压缩强度，以及骨折局部骨痂中胶原和钙的含量。结果显示：在各不同时段，ＸＷ６３０肌注组兔桡骨的抗弯能力与抗压能力明显高于其它各组。在骨折后３０天，其弯曲破坏极限的增加最为明显，分别比Ｃ组、Ｅ２组和Ｔ组高出８０％、７６％和６９％。而在骨折后９０天，ＸＷ６３０肌注组的桡骨弯曲破坏极限已达正常的８０％，分别比Ｃ组、Ｅ２和Ｔ组高出３０％、３４％和１９５％。骨痂胶原含量和骨钙含量的变化与骨抗弯曲能力的变化一致。说明ＸＷ６３０肌肉注射具有明显的促进骨折愈合的作用。采用局部给药方式其各组间无明显差异。在同一时段相同药物组中，肌肉注射给药方式对骨折愈合的作用明显优于局部给药方式。

The aim of this study was to evaluate whether tetracycline estrone (XW630) plays a role in the healing of fracture.120 rabbits were divided into 4 groups and subjected to osteotomies at the middle of both radials,and they were given XW630,estrone (E2),tetracycline (T) and 0.9% sodium chloride (C) respectively after operation by means of intramuscular injection (M) or local injection(L) in the fracture region.The biomechanical properties,including bending and compression,and the biochemical changes were tested at 30 days,60 days and 90 days after osteotomy.The results showed that the bending stress and compression stress in the XW630(M) group were significantly higher than those in other groups at different periods after osteotomy.At 30 days after osteotomy,the bending ultimate stress in the XW630(M) group was 80% higher than that in group C,76% higher than that in group E 2,and 69% higher than that in group T.At 90 days after osteotomy,the bending ultimate stress in XW630(M) group increased to 80% of that of the normal radius,and it was 30% higher than that of group C,34% higher than that of group E2 and 19.5% higher than that of group T.The biochemical changes corresponded with the changes biomechanical properties.These data suggest that XW630 given by intramuscular injection plays an obvious role in accelerating the healing of fracture.The medicine given by intramuscular injection is obviously more effective than that locally injected.