白芍总苷治疗膝关节骨关节炎

Curative Effectiveness and Safety of Total Glucosides of Paeony in the Treatment of Knee Osteoarthritis

目的 :比较白芍总苷与萘丁美酮对膝关节骨关节炎的疗效。方法 :6 0例膝关节骨关节炎患者随机分为白芍总苷治疗组 (A组 )和萘丁美酮对照组 (B组 )各 30例 ,对 2组治疗前、治疗 6周后的患膝疼痛程度、关节压痛度、下肢日常活动能力及医、患双方对病情的评价等 5项指标进行评定。结果 :治疗 6周后 2组症状均有减轻 (P <0 .0 1) ,A组在缓解疼痛、改善下肢功能方面明显优于B组 (P <0 .0 1)。结论 :白芍总苷对膝关节骨关节炎有较好而稳定的疗效 ,值得临床推广。

Objective: To explore the effect of total glucosides of paeony (TGP) in the treatment of osteoarthritis of knee joint. Methods: Sixty cases of knee osteoarthritis were randomly divided into two groups, including 30 cases of TGP treatment group and 30 cases of nabumetone (NAB) control group. Function was evaluated by the patient's lower limb ability of daily life respectively before and 6 weeks after treatment, and involved knee pain was assessed subjectively with a numerical pain scale at the same time. Results: The clinical symptoms in both groups were improved significantly after treatment ( P <0.01). Pain remission and improvement of the lower limb ability of daily life in the TGP group were superior to those in the NAB group ( P <0.01). Conclusion: TGP has preferable clinical curative effect in knee osteoarthritis and is worthy to popularize.