氯沙坦复方制剂治疗轻中度原发性高血压疗效观察

The effect of losartan/hydrochorothiazide combination on mild-and middle essential hypertension

目的 评价复方氯沙坦的降压疗效及安全性。方法 30例轻中度原发性高血压患者 ,每天服复方氯沙坦 1～ 2片 ,观察降压疗效和对实验室检验结果的影响 ,在治疗 1、2、4、6、8周末记录血压、心率及不良反应情况。结果 服药 1周血压即下降 ,收缩压 /舒张压由治疗前的 (15 0 0± 16 8/10 3 2± 5 6 )mmHg降至 (138 6± 13 3/93 3± 6 9)mmHg ,8周后降至 (12 9 2± 12 6 /87 4± 7 8)mmHg ,心率无明显改变 ,不良反应少。结论 复方氯沙坦每天 1次口服 ,能有效控制血压 ,作用平稳 ,不良反应少 。

Objective To evaluate the effect and safety of losartan/hydrochlorothiazide combination(Hyzzar) therapy on mid-to-moderate essential hypertension.Methods All patients(30 cases) received Hyzzar 1～2 pills once daily.Blood pressure and laboratory indexes were measured to evaluate its effect and safety.At the end of 1,2,4,6,8 weeks after treatment,blood pressure,heart rate(HR) and adverse reaction were recorded.Results Systolic blood pressure(SBP)/diastolic blood pressure(DBP) decreased significantly from (150.0±16.8/103.0±5.6)mmHg to (138.6±13.3/93.3±6.9)mmHg after 1 week and to (129.2±12.6/87.4±7.8)mmHg after 8 weeks.There was no change in heart rate.Adverse reactions were slight.Conclusion Hyzzar has a quick and stable effect of lowering blood pressure and is nearly a perfect drug for essential hypertension with little adverse reactions.