摘要
目的 评价活性碳微粒对乳腺癌腋窝淋巴结清扫的临床意义。方法 4 6例乳腺癌病人随机分为两组 ,2 5例活性碳组病人于改良根治术前 4 8～ 72h在瘤床或肿瘤周围腺体内注射活性碳微粒 ,2 1例对照组直接行改良根治术 ,常规清扫腋窝至胸小肌内侧LevelⅢ组淋巴结。结果 活性碳组平均清扫 16 .32个腋窝淋巴结 ,明显多于对照组的 12 .0 0个 (P <0 .0 5 ) ;活性碳组腋窝淋巴结染黑率为 88.8% ( 36 0 4 2 8) ,黑染淋巴结癌转移率明显高于未黑染淋巴结 (P <0 .0 5 ) ,肿瘤直径≤ 1.0cm的淋巴结黑染率明显高于直径 >1.0cm的淋巴结 (P <0 .0 5 )。结论 活性碳微粒能使较小和已有癌转移的淋巴结更易染色 。
Objective\ To evaluate the clinical effect of activated carbon on the axillary lymph node dissection in patients with breast cancer.Method\ 46 patients with breast cancer were divided into two groups randomly. Activated carbon particle was injected into the region around the tumor or biopsy excision in 25 patients (activated carbon group). 21 patients without injection of activated carbon particle were included as control group.Result\ The staining rate of axillary lymph node was 88.8%(360/428) in activated carbon group. The number of dissected axillary node was significantly higher in activated carbon group than that in control group (P<0.05). In activated carbon group, the metastasis rate in stained lymph nodes was significantly higher than that of non-stained lymph nodes (P<0.05), and staining rate of lymph nodes in patients of tumor diameter >1.0 cm was lower significantly than that of tumor diameter ≤1.0 cm (P<0.05).Conclusion\ The use of activated carbon particle enables the small and metastasis axillary lymph nodes to be identified in the patients with breast cancer, which is useful to perform the dissection of axillary node.
