毒蕈碱样乙酰胆碱受体及其拮抗剂在近视发生发展中的作用

Mechanism of muscarinic acetylcholine receptors and antagonists to myopia development

毒蕈碱样受体 (M受体 )是G蛋白偶联受体 ,调节许多重要生理活动。M受体信号的改变 ,在近视发生时的眼球改变中起着重要作用。M受体拮抗剂可以延缓近视进展 ,其中最有效的是阿托品 ,其次是哌仑西平和himbacine,但目前其阻断近视的机制以及作用部位仍未明确。进一步研究M受体及其拮抗剂在近视发生、发展中的作用 ,对深入了解近视发病机制以及有效地防治近视具有重要的意义。

MAChRs are members of a superfamily of receptors that couple to G-pro teins and modulate different kinds of physiological activities. MAChRs are consi dered the critical factors in postnatal ocular development. MAChRs antagonists c an slow the development of myopia,especially atropine,himbacine and pirezepin e. But it's mechanism of blocking myopia is not clear. Studying the function of MAChRs and MAChRs antagonists to myopia is signality to further research the mec hanism of myopia and to prevent mypia.