低硒高镉对大鼠免疫功能及过氧化作用影响的研究

Study on Effects of Low Selenium and High Cadmium on Immunogenic Function and Peroxidation in Rats

用克山病病区粮或加硒和加镉的病区粮喂养S.D大鼠,1～2个月后取其组织进行分析。结果显示:用病区粮饲养大鼠,可使大鼠免疫器官的发育发生障碍,低硒和高镉对大鼠组织的损伤呈现相加作用,加硒可拮抗镉的部分毒性,组织中脂质过氧化物水平与循环免疫复合物的含量呈显著正相关,与还原型谷胱甘肽含量呈显著负相关。说明克山病的致病因素是复杂的,低硒是主要的致病因素,高镉则加重其危害程度,并可能涉及自身免疫病理过程。

To further study the pathogenic factor of the grain produced in the endemic region of Keshan disease and relationship between peroxidation and immunity, feed young S. D rats with the grains produced in the endemic area of Keshan disease. The contents of Se and Cd were controlled by adding Se(Na2SeO3) and Cd(CdCl2). After two months, the rats were killed and a series of analyses was done with their tissues. The results showed that immune organs of rats which were fed on dite with grains produced in the endemic region of Keshan disease were hypoplasia. Low Se and high Cd produced additive injury effects to tissues of rats. Supplementation of Se was partly antagenic on the toxicity of Cd. Lipid peroxidation (LPO) level in tissues was significantly positively correlated to circulatory immunity compound (CIC) level, and negatively correlated to contents of reduced form Glutathione (GSH). These data indicate that the pathogenic factors of Keshan disease are complex. Low Se is a main pathogenic factor. High Cd level could strengthen damages due to low Se level, and a procedure of autoimmunized in Keshan disease maybe exist.