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蛋白酶活化受体-2的研究进展 被引量：1

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摘要 蛋白酶活化受体(protease-activated receptors,PARs)属于G蛋白偶联受体家族成员,其N 末端被蛋白酶裂解后,可形成新的N 末端.新N 末端能够结合、激活自身受体.PAR-2是PARs的成员之一,其激活、灭活、脱敏、复敏及其与信号转导途径的关系,尤其是与疾病(如参与炎症、止血、疼痛与修复)的关系正倍受关注.本文就PAR-2的活化及其在部分组织器官的作用综述如下.
作者 苏林冲 向阳
机构地区 湖北民族学院附属医院内科
出处 《湖北民族学院学报（医学版）》 2004年第2期36-38,共3页 Journal of Hubei Minzu University(Medical Edition)
关键词 蛋白酶活化受体 活化 表达
分类号 R562.1 [医药卫生—呼吸系统]
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参考文献17

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同被引文献22

  • 1杨晓玉,张慧云,何韶衡.蛋白酶激活受体-2与炎症性疾病的关系研究进展[J].陕西医学杂志,2006,35(12):1671-1674. 被引量：3
  • 2胡红心,周红,王婷.蛋白酶激活受体1和2在结肠癌细胞的表达及其作用初探[J].江苏大学学报（医学版）,2007,17(1):23-27. 被引量：11
  • 3周红,胡红心.组织因子在肿瘤细胞的表达及作用[J].血栓与止血学,2007,13(1):36-38. 被引量：6
  • 4钟朝辉,焦岗军,杨燊　,彭吉润,于鑫,董建强,阎征,潘秀英,程西奎,卢军,黄迅.蛋白激酶激活受体-2在人类结直肠癌中表达的研究[J].中华普通外科杂志,2007,22(1):25-28. 被引量：2
  • 5Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease [J]. Physiol Rev, 2004, 84(2): 579-621.
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  • 7Hjortoe GM, Petersen LC, Albrektsen T, et al. Tissue factor-factor Ⅶa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration[J]. Blood, 2004, 103(8): 3029-3037.
  • 8Caruso R, Pallone F, Fina D, et al. Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and Proliferatian[J]. Am J Pathol, 2006, 169 (1): 268-278.
  • 9Kahn ML, Hammes SR, Botkai C, et al. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family[J]. J Biol Chem, 1998, 273(36): 23290-23296.
  • 10Camerer E, Huang W, Coughlia SR. Tissue factor-and factor X dependent activation of protease-activated receptor 2 by factor Ⅶa[J]. Proc Natl Acad Sci USA,2000, 97(10): 5255-5260.

引证文献1

湖北民族学院学报（医学版）
2004年 第2期

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