血清TRAb测定在Graves’病复发中的临床意义

Clinical Significance of Determination of Serum TRAb Levels in Patients with Relapsing Graves’ Disease

目的 :探讨血清促甲状腺激素受体抗体 (TRAb)水平在Graves’病复发中的改变及其临床意义。方法 :对 2 5例Graves’病复发患者 (GD复)、18例初诊Graves’病患者 (GDa)、31例经抗甲状腺药物治疗后甲状腺功能基本正常患者 (GDb)、15例单纯性甲状腺肿患者 (单肿 )、10例结节性甲状腺肿大患者 (结肿 )、18例桥本氏甲状腺炎致甲状腺功能减退患者 (桥本 )分别检测血清TRAb、TT4、TT3 、TSH、FT4、FT3 的水平。结果 :GD复 患者血清TRAb阳性率与GDa相似 ,分别为 76 0 0 %、77 78% ,均显著高于GDb组、单肿组、结肿组和桥本组 (P均<0 0 1)。结论 :血清TRAb检测有助于Graves’病复发的诊断。

Objective To explore the clinical significance of changes of serum TRAb levels in patients with relapsing Graves’ disease. Methods Serum TRAb (with RRA) and seveal other thyroid-related hormones (TT 4, TT 3, TSH, FT 3, FT 4 with CLIA) were determined in the following subjects: 1. 25 cases of relapsing Graves’ disease after previoes successful treatment; 2. 18 cases of recently diagnosed Graves’ disease; 3. 31 cases of successfully treated Graves’ disease; 4. 15 cases of simple goiter; 5. 10 cases of nodular goiter; 6. 18 cases of hypothyroidism due to Hashimoto disease. Results Positive rate of TRAb was 76.00% in patients with relapsing Graves’ disease and 77.78% in recently diagnoced Graves’ disease cases, both being significantly higher than that in all the other sets of patients studied (P<0.01). Conclusion Determination of serum TRAb levels was helpful for the diagnosis of relapse in Graves’ disease.