急性脑出血患者血浆β-EP,NT,NPY的临床观察

Observations on the Levels of Plasma β-EP, NT, NPY in Patients with Acute Intracerebral Hemorrhage

目的 :探讨急性脑出血患者血浆神经肽Y(NPY)、神经降压素 (NT)、β -内啡肽 (β -EP)含量变化及临床意义。方法 :采用放射免疫分析 (RIA) ,检测 32例急性脑出血患者发病第 1、3、7、14d 3种神经肽血浆中的含量变化 ,并设立正常对照组。结果 :(1)急性脑出血病人血浆 β -EP、NPY、NT含量显著升高 (与对照组比较分别为F =31 76 ;F =2 9 80 ;F =7 5 8)。 (2 )发病后血浆神经肽水平最高 ,3d以后较低 ,至第 14d接近正常。结论 :血浆神经肽与急性脑出血病的发病、转归关系密切 ,直接参与急性脑出血病的病理过程 ,对疾病的观察、治疗具有重要意义。

Objective To explore the clinical significance of changes of plasma contents of neuropeptide Y (NPY)、 neurotensin (NT) and β-endorphin (β-EP) in patients with acute cerebral hemorrhage. Methods Serum levels of NPY、 NT、 β-EP were measured with RIA in 32 patients with acute intracerebral hemorrhage immediately after admission as well as 35 controls. Measurements were repeated on d3, d7 and d14 in the patients. Results (1) Serum levels of NPY、 NT、 β-EP were significantly higher than those in the controls (F=31.76, F=29.80, F=7.58 respectively, P<0.01). (2) The levels were highest immediately after admission and dropped gradually from d3 to d17, finally approaching control value. Conclusion Monitoring serum NPY, NT and β-EP levels were useful for following the the progress of the disease.