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BRCA1与DNA损伤修复及转录调节 被引量：1

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摘要 BRCA1基因定位于人染色体 1 7q1 2 2 1 ,编码蛋白含有 1 86 3个氨基酸残基。BRCA1蛋白具有许多与其他蛋白相互作用的位点 ,通过蛋白之间的相互作用来发挥其重要的生物学功能 ,包括细胞周期调控 ,DNA损伤修复 ,基因的转录调节 ,细胞凋亡和泛素化等。BRCA1基因的突变与家族性乳腺癌及卵巢癌的发生密切相关 ,对BRCA1分子功能尤其是DNA损伤修复和转录调节的研究 ,将有利于阐明肿瘤发生的机理。因此本文就BRCA1的结构及其在DNA损伤修复和转录调节方面的研究进展做一综述。
作者 王涛 曹雪涛
机构地区 浙江大学免疫学研究所 第二军医大学免疫学研究所
出处 《国外医学（免疫学分册）》 2004年第4期202-206,共5页 Foreign Medical Sciences(Section of Immunology Foreign Medical Sciences)
关键词 BRCA1 DNA损伤修复 转录调节
分类号 R737.9 [医药卫生—肿瘤]
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参考文献25

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同被引文献11

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  • 7Zhang H, Zhang S,Cui J, et al. Expression and promotermethylation status of mismatch repair gene hMLHl and hMSH2in epithelial ovarian cancerfj]. Aust N Z J Obstet Gynaecol,2008,48(5): 505-509.
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引证文献1

国外医学（免疫学分册）
2004年 第4期

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