保持自发性高血压大鼠的高血压特性——SHR大鼠受孕与产仔率及血压的实验观察

Characteristics of Hypertension Maintained in Spontaneously Hypertensive Rats: Observation on Conception Rate, Litter Size and Blood Pressure of SHR

目的 保持自发性高血压大鼠 (SHR)的高血压特性。方法 采取兄妹交配方法 ,观察记录SHR 2年的受孕率及产仔数。分别于 1 2、1 6、2 0周龄测量种鼠的收缩压和心率。结果 第一年度生产 3代 ,平均SHR受孕率及孕鼠平均产仔数分别为 77 5 %与 7 4只 ,SHR受孕率低于同期京都威斯特大鼠 (WKy)受孕率 (90 .0 % ) ,但差异不显著 (P =0 1 2 ) ;SHR平均产仔数高于WKy(6 5只 ) (P =0 0 1 )。第二年度生产 2代 ,平均SHR受孕率及孕鼠平均产仔数分别为 82 7%与 6 9只 ,SHR受孕率及平均产仔数高于同期WKy(5 8 8% ,P =0 0 0 1 ;4 3只 ,P <0 0 0 1 )。第一年度第 1 2、1 6、2 0周龄时雄鼠收缩压平均值为 (1 87 7± 9 0 ) ,(1 97 0± 7 5 )和 (1 99 0± 7 6 )mmHg(1kPa =7 5mmHg) ,第二年度第 1 2、1 6、2 0周龄收缩压平均为 (1 77 5± 1 0 7) ,(1 97 9± 7 2 )和 (1 99 7± 6 8)mmHg。结论 SHR繁育能力近似于WKy;

Objective To maintain the characteristics of hypertension in spontaneously hypertensive rat(SHR) Methods The breeding of rats were used for brother-sister mating The conception rate and the offspring number per litter of SHR were recorded for 2 years The blood pressure and heart rate of SHR were measured at 12,16,20 week-old Results First year,the mean conception rate of SHR was lower(77 5%) than WKy(90 0%; P =0.12),and the offspring number per litter was higher(7 4 rats) than WKy(6 5 rats; P =0 01)for three generations Second year,the average conception rate and the offspring number per litter of SHR were higher(82 7% and 6 9 rats) than WKy(58 8%, P =0 001;4,3 rats, P <0 001) for two generations The average systolic blood pressure(SBP) in males at 12,16 and 20 week-old in the flrst year were 187 7±9 0, 197 0±7 5 and 199 0±7 6 mmHg Second year,the average SBP in males at 12,16 and 20 week-old were 177 5±10 7,197 9±7.2 and 199 7±6.8 mmHg respectively Conelusion The productive performance of SHR was similar with WKy;the characteristics of hypertension in SHR were maintained for 2 years