金匮肾气丸对大鼠肾阳虚模型的影响

Effect of Jinkuishenqiwan on the Kidney-Yang Deficiency in Rats

目的 研究金匮肾气丸对大鼠肾阳虚模型的治疗作用。方法 将大鼠分为 5组 :正常组、模型组、治疗组 (高、中、低剂量组 ) ,除正常组外 ,其他组大鼠用氢化可的松注射液制造肾阳虚模型 ,尔后 ,正常组和模型组给予等体积的蒸馏水 ,而治疗组给予相应剂量的金匮肾气丸 ,持续 2 0d。最后测定超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH -PX)、丙二醛 (MDA)及睾酮含量 ,并计算脏器系数。结果 治疗组大鼠血清中的SOD、GSH -PX、睾酮含量较模型组明显升高 ,MDA含量显著降低。同时与模型组比较 ,治疗组体重明显高于模型组 ,肾脏系数明显降低 ,其中高剂量组睾丸系数明显升高。

Objective To study the effect of Jinkuishenqiwan(JKW) on the model of kidney-Yang deficiency in rats. Methods Rats were devided into five groups:normal group, model group,therapeutic groups(high,middle,low dose). Except the normal group,the others were made into model of kidney yang deficiency by injecting hydrocortisone. After that, normal and model groups were given equal distilled water , therapeutic groups were given corresponding dose of JKW for twenty succesoive days. In the end, contents of SOD,GSH PX,MDA,testosterone and the organ indexes of every group were determined.Results The contents of SOD,GSH PX,testosterone were obvious higher and the contents of MDA were lower in therapeutic groups than in model group. Meantime,in the therapeutic groups the body weight was higher, the renal indexes were lower than in the model group. And the testis indexes of the high dose group were obvious higher. Conclusion It is indicated that JKW exerts a certain therapeutic effect on the kidney yang deficiency in rats.