SARS感染对妊娠结局及胎、婴儿的影响

Effects of SARS during pregnancy on the pregnant outcome

目的 观察中晚期妊娠合并严重急性呼吸综合征 (severeacuterespiratorysyndrome,SARS)对妊娠结局及胎婴儿的影响。 方法 分析 6例妊娠合并SARS的临床特征、妊娠结局 ,检测母儿SARS病毒抗体、RNA ,随访婴儿情况。 结果 6例 (双胎妊娠 2例 )SARS患者娩出新生儿 7例 ,其中早产 2例 ,胎儿窘迫 3例 ;1例双胎妊娠之一胎儿死亡 ,另一胎儿生长受限 ;新生儿均无窒息、SARS迹象。产妇冠状病毒抗体IgG均阳性 ,婴儿 4例阳性、3例阴性 ;母儿IgM抗体、病毒RNA均阴性。早产儿 (3例 )体格智能发育稍落后 ,足月儿 (4例 )正常。 结论 中晚期妊娠合并SARS对围产结局有一定的不良影响 ,但未发现SARS病毒的垂直传播。

Objective To study the effect of SARS during pregnancy on the pregnant outcome. Methods Six pregnant women who suffered from SARS in the second or third trimester were observed. The fetuses and infants were followed up. SARS specific antibody and coronavirus RNA were detected in blood and pharyngeal secretion samples for both mothers and their infants. Results Among the 6 cases,2 were twins. Two cases were preterm birth,3 were fetal distress. One fetal death in one twin,the other fetus complicated with fetal growth restriction. None of the 7 neonates had asphyxia or any signs of SARS.SARS coronavirus IgG was positive in 7 mothers and 4 infants. SARS specific IgM and coronavirus RNA were negative in all 7 newborns. Physical and mental development in 3 premature infants was slightly delayed while normal in the 4 full-term infants. Conclusions SARS during pregnancy may have some harmful effects on the perinatal outcome. No intrauterine transmission of coronavirus has been found.