原发性高血压患者血清胰岛素样生长因子Ⅱ、生长激素和胰岛素变化的探讨

Serum insulin-like growth factor Ⅱ,growth hormone and insulin in essential hypertension

目的 探讨原发性高血压患者血清胰岛素样生长因子 (IGF )、生长激素 (GH )和胰岛素(IS)变化及其临床意义。方法 用放射免疫法测定 92例原发性高血压 (EH)患者和 4 5例非高血压患者的血清 IGF 、 GH和 IS水平 ,并进行对照统计分析。结果 EH组血清 IGF 和 IS水平显著高于对照组 (P<0 .0 1) ,而 GH水平显著低于对照组 ,IGF 和 GH、GH和 IS间呈显著负相关 (P<0 .0 5 ) ,IGF 和 IS与平均动脉压成显著正相关 (P<0 .0 5 ) ,GH与平均动脉压无显著相关性。男女组间均值比较均无统计学差异。在 、 、 期组间 ,血清 GH水平依次递减 (方差分析 ,P<0 .0 1) ,且 期组显著低于 期组 (P<0 .0 5 ) ,伴心脑肾并发症组血清 GH水平亦显著低于无并发症组 (P<0 .0 5 ) ;血清 IGF 和 IS水平则均无统计学意义。结论 EH患者血清 IGF 和 IS水平显著升高 ,而 GH水平显著降低 ,GH和 IGF 、GH和 IS负相关 ,且 IGF 和 IS与平均动脉压正相关 ,三者变化与性别无关 ,随着病情进展 ,GH有进一步降低趋势 ,但 IGF 和 IS无此趋势。

Objective] To investigate the changes of serum insulin-like growth factor Ⅱ(IGF Ⅱ),growth hormone(GH)and insulin(IS)in patients of essential hypertension(EH). To investigate the changes of serum insulin-like growth factor Ⅱ(IGF Ⅱ),growth hormone(GH)and insulin(IS)in patients of essential hypertension(EH). Serum IGF Ⅱ,GH and IS were studied in 92 cases of EH by radioimmunoassay,45 normtensive patients were served as control. Serum IGF Ⅱ and IS was increased significantly in EH compared with that in the control group(P<0.01),but serum GH was decreased significantly.The serum IGF Ⅱ and IS level were negative correlated significantly with the GH(P<0.05).IGF Ⅱ and IS were positively significantly correlated with the mean artery pressure level(P<0.05),but GH was not so.They were not changed significantly in male patients vs in female.GH was most markedly decreased in Ⅲ stage EH to I stage,and the difference in the mean serum GH levels was significantly in different stages(stage Ⅰ.Ⅱ.Ⅲ)EH patients(P<0.01).In EH patients with heart and/or brain and/or renal complications was significantly lower than in EH patients without complications(P<0.05),but no significan difference for IGF Ⅱ and IS.[Conclusion] Serum IGF Ⅱ and IS is increased in EH patients,but GH is decreased significantly the most markedly decrease in Ⅲ stage hypertensives for GH.