摘要
目的 观察灵芝多糖降血糖的作用 ,探讨它降血糖的可能机理。方法 应用药物建立糖尿病大鼠模型、分组并给予不同剂量的灵芝多糖 ,观察血糖、胰岛素、葡萄糖激酶等指标。结果 灵芝多糖能显著降低血糖 ,增加胰岛素的分泌 ,修复胰岛细胞 ,增加葡萄糖激酶的活性。结论 口服灵芝多糖可降低糖尿病大鼠的高血糖、升高胰岛素水平 ,可能是通过灵芝多糖对胰岛细胞的不同程度的修复 ;灵芝多糖可促进糖尿病大鼠体内的葡萄糖磷酸化。
Objective ]observing the hypoglycemic effect of GLP,and its action mechanism is also preliminary explored.observing the hypoglycemic effect of GLP,and its action mechanism is also preliminary explored. establishing the SD rats model and divided them into 5 groups randomly and ig different dose with GLP,measuring blood sugar,insulin,liver glucokinase,liver glucogen. GLP decreases blood sugar,increases insulin secretion,recover the B cells and improve the liver glucokinase activity.[Conclusion] GLP has dramatic hypoglycemic activity,it can promote insulin secretion through recovery the B cells which were damaged by alloxan and improve the liver glucokinase activity.
出处
《福建医药杂志》
CAS
2004年第3期137-140,共4页
Fujian Medical Journal
基金
浙江省教育厅科研基金资助
