产后垂体增大的MRI随访及临床生化探讨

Clinical biochemistry and MRI follow up study in postpartum pituitary enlargement

目的探讨产妇垂体的增大及其与临床生化的关系。方法对6例产妇产后特别是产褥期内的垂体进行MRI扫描及临床生化检测观察。结果6例产妇垂体增大以产褥期第1周内最显著,此时内分泌变化产后1周特别是产后第1、2天内β亚基绒毛膜促性腺激素(βHCG)、孕酮(PRG)、雌二醇(E2)等呈较高测量值,催乳素(PRL)增高,1周后HCG、PRG、E2等迅速减退,垂体大小也恢复至正常。结论产后垂体增大系生理性的,与产妇孕期内环境变化有关,不要误认为异常。

Objective To investigate the relationship between enlargement of pituitary in postpartum females and the clinical biochemistry. Methods In total 6 postpartum women were studied by MRI of pituitary and clinical biochemistry assessment, the data was collected especially in puerperium period. Results Enlargement of pituitary gland was most remarkable in the first week of puerperium period, while endocrine changes including HCG,Progesterone,E2 also reached considerable high peak in the same time especially the first and second day after labor. Prolactin also increased. βHCG, Progesterone, and E2 rapidly decreased after the first week of puerperium period and the size of pituitary gland recovered to normal size.Conclusion Postpartum enlargement of pituitary gland is physiological and related with internal environment change in gravitation, which is not to be misdiagnosed as a lesion.