金属蛋白酶MMP-2在肺癌中的表达及预后

The Relationship Between Expression of Matrix Metallproteinase-2 and Prognosis in Lung Cancer

目的 :探讨基质金属蛋白酶MMP 2在肺癌组织中的表达及与肺癌临床病理特征及预后的关系。方法 :用免疫组织化学的方法观察肺癌组织的MMP 2的表达。结果 :肺癌组织中MMP 2的表达显著高于正常肺组织 ,与临床分期、淋巴结转移有显著相关性。临床分期越高 ,MMP 2的表达越呈增加趋势 ,且随着MMP 2的表达增高而患者的生存期降低。结论 :MMP 2参与肺癌的侵袭和转移 。

Objective: To investigate the expression of MMP-2 in lung carcinoma and it’s relationship with clinical pathological characteristics and the prognosis of the disease. Methods: S-P immunohistological staining was used to detect the expression of MMP-2 in 58 cases of lung carcinoma and 58 cases of normal lung tissues. Results: The expression rates of MMP-2 were 63.8% and 31% in lung carcinoma tissue and normal lung tissue respectively. There was significant difference of expression between them, and the MMP-2 expression was closely correlated to lymph node metastasis and clinical stages. High carcinomatous MMP-2 values were of prognostic significance for poor survival of the patients. Conclusion: The expression of MMP-2 is closely correlated to lymph node metastasis and the clinical stages of lung carcinoma, and it might serve as a parameter for determining invasive and metastasis behavior of the tummor.