原发性高血压患者血清脑利钠肽、血管紧张素Ⅱ、内皮素的变化及意义

Serum Brain Natriuretic Peptide and Angiotensin Ⅱ and Endothelin in Essential Hypertension

目的 :探讨原发性高血压患者血清脑利钠肽 (BNP)、血管紧张素Ⅱ (AngⅡ )和内皮素 (ET)的变化及其临床意义。方法 :用放射免疫法测定了 1 2 6例原发性高血压 (EH)患者和 49例非高血压患者的BNP、AngⅡ和ET水平 ,并进行对照统计分析。结果显示 :EH组血清BNP、AngⅡ和ET水平显著高于对照组 (P <0 0 1 ) ,且均与平均动脉压 (MAP)成显著正相关 (P <0 0 5)。但与体重指数 (BWI)无相关性意义。男女组间无统计学差异。Ⅰ、Ⅱ、Ⅲ期组间均呈显著性递增 (P <0 0 1 ) ,但Ⅰ期组与对照组无显著差异 (P >0 0 5)。伴心脑血管并发症组三项指标均显著高于无并发症组 (P <0 0 1 )。结论 :EH患者存在明显的血清BNP、AngⅡ和ET水平的变化 ,且这种变化与EH分期、MAP相关 ,提示BNP、AngⅡ和ET的变化与病情进展、预后相关。

Objectve:To investigate the changes of serum Brain Natriuretic peptide(BNP) and Angiotensin Ⅱ(Ang Ⅱ)and Endothelin(ET)in patients of essential hypertension(EH),and its clinical significance.Methods:Serum BNP and AngⅡ And ET were studied in 126 cases of hypertension by radioimmunoassay,49 normotensive patients were served as control.Results:Serum BNP and Ang Ⅱand ET were increased significantly in EH patients compared with that in the control group(P<0.01),and positively significantly correlated with the mean artery pressure level(P<0.05),and negatively significantly correlated with weight index.No difference in male patients compared with that in female.They were markedly increased in Ⅲ stage VS Ⅱ stage(P<0.01),also in Ⅱ stage VS Ⅰstage(P<0.01),and increased significantly in patients complicated with cardio-cerebro-vascular diseases vs that without complications.Conclusion:Serum BNP and Ang Ⅱand ET were increased in EH patients,and markedly increased in Ⅰ,Ⅱ,Ⅲstages patients,and correlaeed with the mean artery pressure level.It shows BNP and Ang Ⅱ and ET were correlated with state of an illness in EH,and correlated with development and prognosis of EH patient.