盐酸金霉素含量及相关物质测定

Determination of Chlortetracycline Hydrochloride and Related Substance

目的 采用中国药典 Ch P2 0 0 0测定盐酸金霉素含量及相关物质 ,检测时间长、分离效果差且检测结果偏差大。本文中的方法具有检测时间短、操作简单、准确等优点 ;该方法在所测定的范围内具有良好的线性 (相关系数 r>0 .99) ,重复测定及耐用性的相对标准偏差均小于 2 %回收率均在 95 .0 %～ 10 5 .0 %之间。结果该方法表明测定盐酸金霉素含量及相关物质是一种简便、准确的分析方法。

Chlortetracycline hybrochloride tests assay and related substance with Chinese pharmacopoeia ChP2000 and this method Excellent and bad better of two test method comparison the better more bad.The testing time is long and separation effect is bad and detect result deviation is big by Chinese pharmacopoeia It is short this method have detection time,operating simple accurate etc.advantage;This method has good Linearity in the detectrange(Relative coefficientr>0.99),the relative standard deviation of repetitive test and durableness is smaller than 2%,Recovery rate is 95.0%～105.0%.As a result,show that Chlortetracycline hydrochloride test assay and related substance with this method are a kind of simple and accurate analysis method.