摘要
大量研究表明 ,神经递质系统如多巴胺递质系统、5 -HT递质系统、谷氨酸递质系统和信号传递途径如 AC-c AMP-PKA-CREB、NO-c GMP、Ca2 + -Ca M-Ca MK-CREB等参与了药物 (特别是吗啡类 )依赖性的形成 ,进一步探讨它们在依赖中的作用 ,可以为最终阐明药物依赖性的形成机制和研发戒毒药提供新的思路。
Several studies suggested that some neurotransmitters such as dopamine,5-HT,aminoglutaric and some signal pathways such as AC-cAMP-PKA-CREB、NO-cGMP、Ca 2+ -CaM-CaMK-CREB are critically involved in the process of drug dependence, especially morphine like compound; It can offer new idea to clarify finally the mechanism of drug dependence and to research and develop the new drug if we further explore their role in the drug dependence.
出处
《海峡药学》
2004年第3期1-6,共6页
Strait Pharmaceutical Journal
关键词
药物依赖性
神经递质
信号通路
Drug dependence
Neurotransmitter
Signal pathway
