孤独症儿童神经发育异常评定的研究(英文)

Neurodevelopment anomalies assessment in autistic children

目的探讨儿童孤独症早期神经发育异常的评定与测量。方法采用发育异常评定量表(DAS)对45例各个符合国际疾病诊断与分类(ICD-10)诊断标准的孤独症儿童和28例精神发育迟滞儿童及21例正常对照组儿童分别进行评定;采用儿童孤独症证定量表(CARS)、孤独症儿童行为检查表(ABC)对发育异常评定高分组(DAS≥5分)与发育异常评定低分组(DAS<5分)分别进行评定,对评定结果进行组间比较。结果孤独症儿童的轻微躯体异常评定量表(MPAS),手发育不良评分(HMS),增被项目评分及发育异常评定量表部分(DAS)均高于正常对照组,MPAS及DAS评分两组之前存在显著性差(<0.01)。孤独症儿童的轻微身体异常评定量表(<0.01,<0.05)。孤独症儿童发育异常评定高分组(DAS≥5分)与发育异常评定低分组(DAS<5)的ABC及CARS量表评定结果无显著性差异。结论孤独症儿童存在胚胎期神经发育不良。

Objective: To explore the evaluation and measurement of early stage neurodevelopment anomalies in autistic children. Methods: 45 outpatients satisfying the ICD-10 criteria for child autistic disorder, 28 patients with mental retardation and 21 normal controls were examined by development anomalies scale (DAS), patients with autism were also examined with child autism rating scale (CARS) and autism behavior check list (ABC). Results: The score of minor physical anomalies scale (MPAS), hand mal-development score (HMS), supplemental items and total score of DAS in autistic group were higher than those in normal control group, and there was a significant difference between autism group and normal control group (P <0.01). The score of MPAS, supplemental items and total score of DAS were significantly lower than that of mental retardation group (P <0.01, P <0.05). There was no significant difference between DAS high anomalies group (DAS≥5) and DAS low anomalies group (DAS<5) by CARS and ABC evaluation. Conclusion: Autistic children have a neurological mal-development in the embryonic stage.