巴比妥经不同皮肤层吸收差异的评价(英文)

Influence of different layers of skin on the percutaneous absorption of barbital

目的 评价皮肤角质层和活性皮肤层对药物经皮吸收的差异。方法 选择巴比妥(BB)为模型药物,采用Franz吸收池法,考察药物经完整皮肤和剥离角质层皮肤的体外透皮能力Kp,并比较吸收促进剂肉豆蔻酸异丙酯(IPM)共存时的促透能力大小。结果 BB经剥离角质层皮肤的Kp是经完整皮肤的2.37倍,加入IPM后BB的Kp分别提高到原来的2.59倍(经完整皮肤)和6.92倍(经剥离角质层皮肤)。结论 本实验为皮肤病态条件,如皮肤受伤或溃疡等时的药物经皮吸收提供实验依据。

Objective: To investigate the influence of skin layers (stratum corneum and viable layer) on the percutaneous absorption of drug with or without isopropyl myristate (IPM). Methods: Barbital (BB) was chosen as a model drug. Patches containing saturated concentration of BB were prepared. The in vitro percutaneous permeation experiment via different rat skin layers was carried out. Results:The Kp of BB via stripped skin was 2.37 times larger than that via intact skin. The permeability was enhanced when coexisting with IPM via both intact skin and stripped skin. Conclusions:These data and methods could be a novel approach to evaluate the effects of skin damage and skin disease on drug percutaneous absorption.