摘要
目的:探讨冠心病患者血尿酸水平的变化及对左心室功能的影响。方法:87例经冠状动脉造影证实的冠心病患者(54例)和非冠心病患者(33例),比较两组患者的血尿酸水平、左心室舒张末期内径及左心室功能状况。结果:冠心病患者的血尿酸水平、左心室舒张末期内径明显高于非冠心病患者[分别为(323.71±85.94)μmol/Lvs.(285.92±57.73)μmol/L,(51.65± 5.58)mm vs.(47.66±4.99)mm,P<0.05]。血尿酸水平与左心室舒张末期内径呈正相关(P=0.033),与左心室射血分数呈负相关(P=0.012)。冠心病患者中,男性血尿酸水平明显高于女性(P<O.05)。结论:尿酸可能在冠心病的发病过程中起着关键作用,并可能通过促进心室重构进而影响到患者的左心室功能状况。
Objective: The study was designed to analyze the level of serum uric acid and its effect on cardiac systolic function
in patients with and without coronary heart desease (CHD). Methods: 87 cases who undergoing coronary angiography were consecutive-
ly divided into 2 groups: CHD group (54 cases) and non-CHD group (33 cases). The level of serum uric acid, the size of left ventric-
ular end-diastolic diameter(LVEDD) as well as the left ventricular ejection function (LVEF) were deternined and analyzed. Results:
The level of serum uric acid and the size of LVEDD in CHD group were significantly higher than that of non-CHD groupl[(323. 71±
85. 94) μmol/L vs. (285. 92±57. 73)μmol/L, (51. 65±5. 58)mm vs. (47. 66±4. 99)mm,respectively, P<0. 05]. There was a
positive correlation between the serum uric acid level and the value of LVEDD(P=0. 033), and a negtive correlation between serum
uric acid level and the value of LVEF(P=0. 012). In CHD group, the level of serum uric acid of male was significatly increased com-
pared with that of female(P<0.05). Conclusion: Uric acid may play a key role in the development of CHD, and may probably in-
flunce the condition of cardiac function in patients with CHD through promoting ventricular remodeling.
出处
《中国医药导刊》
2004年第3期162-163,168,共3页
Chinese Journal of Medicinal Guide
