血浆同型半胱氨酸水平与颈动脉内膜中层厚度的关系

The Relationship between Plasma Homocysteine and Carotid Intima-medial Thickness

目的:探讨血浆同型半胱氨酸水平与颈动脉内膜中层厚度的关系。方法:取空腹静脉血利用高效液相层析法测定血浆同型半胱氨酸的浓度。利用高分辨率超声仪测定双侧颈动脉内膜中层厚度,动脉粥样硬化的定义为内膜中层厚度(IMT)≥1.3mm,根据超声结果分为颈动脉粥样硬化组(IMT≥1.3mm)和对照组(IMT<1.3mm)。结果:颈动脉粥样硬化组血浆同型半胱氨酸水平明显高于对照组,差异有显著性(P<0.05)。颈动脉粥样硬化组高同型半胱氨酸血症的检出率高于对照组(49.1％/9.8％ X^2=14.6 P<0.01)。Logistic回归分析显示血浆同型半胱氨酸水平与颈动脉粥样硬化发生相关(OR=2.011,P=0.033)。结论:颈动脉粥样硬化患者血浆同型半胱氨酸水平明显升高,高同型半胱氨酸血症的检出率高。血浆同型半胱氨酸是预测颈动脉硬化的独立危险因素。

Objective: To investigate the relationship between plasma homocysteine and carotid intima--medial thickness. Meth- ods: Plasma total homocysteine concentration was determined by highperformance liquid chromatogrphy for with fluorescence detec- tion. Ultrasonographic scanning of the bilateral common carotid arteries were performed, and the intima--medial thickness was measured. Intima--medial thickness≥1. 3 mm was difined as atherosclerosis. 91 patients were divided into carotid atherosclerosis group and control group.Results: Plasma toal homocysteine levels were significantly higher in petients with intima--medial thickness≥1. 3mm than those who with intima--medial thickness <1. 3 mm. More cases of hyperhomocysteinemia were found in carotid atherosclerosis dis- ease patients than in the controls. Logistic regression analysis showed that plasma total homocysteine levels were associated with carotid atherosclerosis(OR=2. 011, P=0. 033). Conclusion: Plasma total homocysteine levels were higher in carotid atherosclerosis disease patients than the controls. More cases of hyperhomocysteinimia were found in carotid atherosclerosis disease petients. Plasma total homocys- teine level were independent factors of atherosclerosis.