血清癌抗原125对卵巢恶性肿瘤诊断及监测复发的价值

Diagnostic and recurrence value of serum CA125 on malignant ovarian tumor

目的 :探讨癌抗原 12 5 (CA12 5 )对卵巢恶性肿瘤诊断及复发的价值。方法 :应用化学发光法测定了 6 7例卵巢恶性肿瘤、6 2例卵巢良性肿瘤、2 0例子宫内膜异位症及 18例盆腔炎性包块患者血清 CA12 5值。结果 :卵巢恶性肿瘤的血清 CA12 5值及阳性率明显高于其他 3组患者 ,差异有显著性 ;血清 CA12 5值 >2 0 0 u/ m l,诊断卵巢癌的特异性达 10 0 % ,敏感性 4 9.2 5 % ;6 7例中 12例复发患者 CA12 5平均值为 2 0 3.86 u/ ml,8例血清 CA12 5阳性 (6 6 .6 6 % )。结论 :监测血清 CA12 5对卵巢癌的诊断有重要意义 ,对卵巢癌复发的监测亦有一定的价值 ,但不能作为惟一的监测手段。

Objective: To study diagnostic and recur value of serum CA125 on malignant ovarian tumor. Methods By using radiochemistry, CA125 concentration in serum was measured in 67 patients with malignant ovarian tumor, 62 patients with benign ovarian tumor,20 patients with endometriosis and 18 patients with pelvic inflammation. Results the serum CA125 concentration in malignant ovarian tumor was higher than that in other three groups; The peculiar rate (100%) and sensitive rate (49.25%) of ovarian cancer using serum CA125>200u/ml;the serum average CA125 in 12 cases of recurrent ovarian cancer was 203.86u/ml,8 of 12 cases have abnormal CA125(66.66%). Conclusion:It is important to measure serum CA125 for diagnosis of ovarian cancer,and there are some values for recurrent ovarian cancer. But it is not the only measuring method.