充血性心衰病人血浆心钠素浓度的变化和意义

The levels of plasma atrial natriuretic peptide in the patients with congestive heart failure

本文观察了60例充性性心衰病人和69例正常人血浆心钠素浓度,对部分病人进行了治疗前后动态观察;另对无明显心衰的29例心脏病人作了心钠索和血液动力学同步测定.结果是大部分心衰病人血浆心钠素水平升高,少数严重病例降低;心钠素水平随心衰的改善或加重而降低或相对升高;心钠素浓度与24小时尿排钠量、CVP、RAP、PCWP 等呈正相关,与 CI 呈负相关。并对心衰时心钠素水平变化的意义进行了讨论。

Plasma atrial natriuretic peptide(pANP)levels were measured in 60 patients with congestive heart failure(CHF)and 69 healthy subjects.Another 29 cardiopathic patients without any sign of CHF also underwent pANP and hemodynamic detexmination simultaneously.The results showed that the majority of patients with CHF had an elevated pANP level,but a few patients with seroous clinical condition stowed lower pANP levels than controls.pANP levels fell remarkably with the improvement of clinical state after treatment.A correlation was obseived between pANP and right atrial pressure or pulmonary capillary wedge pressure.The mechanisms and clinical significance of variant changes of pANP in CHF were discussed.