原发性高血压患者高凝状态的研究

Study on the hypercoagulant state in essential hypertension

随机选择原发性高血压患者112例,其中有靶器官损害者48例,无靶器官损害者64例;另选102名健康人为对照组,进行凝血功能检查。结果是:高血压组 APTT、TT 较对照组显著缩短,Fbg,Ⅷ:C、ⅧR:Ag 显著升高(P<0.05),ATⅢ:C 显著降低。各项凝血指标:在有、无靶器官损害患者间,均无显著性差异。而高凝状态的发生率,高血压组为22.3%,对照组仅4.9%(P<0.01)。提示:原发性高血压患者血液的高凝状态有致血栓形成倾向,这种倾向可能与高血压病患者易并发一过性脑缺血、脑卒中及冠心病密切相关.

In random selected 112 essential hypertensive patients,48 eases had target organ demage.In all of them,coagubitity of blood was examined.Another 102 healthy individuals were examined also as control group.In the 112 hypertensive cases the incidence of hypercoa- gulant state was 22.3%,and in the control group was only 4.9%(P<0.01).The results suggest that in essential hypertensive cases the hypercoagulant state may predispose the tendency of thrombosis.This may be closely related with the complications of transient ischemic attack,stroke and coronary hoart disease.