纳米红色元素硒在Beagle犬的药代动力学分析

Pharmacokinetic study of the nano red elemental selenium in Beagle dogs

目的 :观察纳米红色元素硒 (Nse)在Beagle犬的药代动力学特点。方法 :催化荧光法测定用药前基线值和用药后不同时间血硒浓度 ,分别用血硒实测值和上升值计算药动学参数。结果 :Nse代谢符合一室模型 ,吸收较快 ,药峰值为 15 5mg·L-1(实测值 )和 135 .4mg·L-1(上升值 ) ,达峰时间约为 2h ,但消除较慢 ,清除率极低 ,t1 2 长达 34.6h(实测值 )和 2 0h(上升值 )。结论 :长时间、大剂量服用Nse可能导致药物蓄积 ;体内具有基线值时 ,计算药动学参数宜用变化值 。

AIM: To study the pharmacokinetics of the nano red elemental selenium (Nse) in Beagle dogs. METHODS: Blood levels of selenium were determined before and different times after administration. The observed values and increased values (observed value plus baseline) of blood levels of selenium were used to calculate pharmacokinetic parameters. RESULTS: Nse conformed to one-compartment model with fast absorption and slow elimination. T 1/2 was 34.2 h by observed values in calculation and 20 h by increased values. CONCLUSION: Nse leads to toxicity easily in the administration with long term and large dose. For the material with baseline in body, the pharmacokinetic analysis should use the increased values to calculate parameters.