热休克蛋白70在卵巢癌组织中的表达及其与雌、孕激素受体的相关性

Expression of Heat Shock Protein-70, Estrogen Receptor and Progesterone Receptor in Ovarian Carcinomas and the Correlation Between HSP70 and Sex Steroid Receptor

目的 检测卵巢癌组织中热休克蛋白 70 (heat shock protein- 70 ,HSP70 )、雌激素受体 (estrogenreceptor,ER)、孕激素受体 (progesterone receptor,PR)的表达 ,探讨 HSP70与甾体激素受体之间的关系。方法 采用免疫组化 SP法检测 4 1例卵巢癌、1 1例正常卵巢组织中 HSP70、ER、PR的表达。结果 4 1例卵巢癌中 HSP70阳性率为 6 8.2 9% (2 8/ 4 1 ) ,明显高于正常组织 (1 8.1 8% ) (P<0 .0 5 ) ,而且 HSP70在低分化卵巢癌中的阳性率明显高于高分化癌 (P<0 .0 5 )。ER阳性 1 9例 (4 6 .34% ) ,PR阳性 2 4例 (5 8.5 4 % )。ER、PR在 HSP70阴性组的表达高于 HSP70阳性组。结论 HSP70与 PR的表达呈负相关 (P<0 .0 5 )

Objective This study was aimed to determine the expression of HSP70, ER and PR in ovarian carcinomas and to explore the relationship between HSP70 and sex steroid receptor. Methods The immunohistochemical way SP was performed to estimate the expression of HSP70, ER and PR in 41 cases of ovarian carcinomas and in 11 cases of normal ovarian tissue. Results The positive staining rate of HSP70 was 68 29% (28/41), which was remarkably higher than that in normal ovarian tissue (18.18%) ( P < 0.05). Furthermore, the expression rate of HSP70 was much higher in poorly differentiated ovarian carcinomas than in well differentiated ovarian carcinomas ( P <0.05). ER positive staining was observed in 19 cases (46.34%),and PR in 24 cases (58.54%). ER and PR positive staining occurred more frequently in the group of HSP70 negative staining than in the group of HSP70 positive staining. Conclusion The expression of HSP70 was negatively related with the expression of PR ( P <0.05).