硝酸甘油、肝素连续静滴治疗不稳定型心绞痛

Nitroglycerine,heparine Ⅳ management of unstable angina pectoris

报告用 NTG、肝素连续静滴治疗不稳定型心绞痛57例,与11例常规治疗的对照组比较,效果非常显著(前者显效94.7%,后者45.5%,P<0.01)。治疗组于治疗后血 T_xB_2由438±179.4降为173.7±62.93ng/ml(P<0.001),血小板聚集堆由31.8%降为20.3%(P<0.05),病人全部脱险;对照组2例(18%)转为 AMI,1例(9.1%)死亡。提示在不稳定型心绞痛早期使用 NTG、肝素静滴可防止 AMI 的发生,并能缓解有关症状。

Nitroglycerin(NTG) and heparin(H)were given by continuous drip in 57 patients with unstable angina peetoris.Another same 11 cases were treated by ordinary method served as control.Angina pectoris was subsided in 54(95%)of NTG and H treated group,and in 5(45.4%) of control group(P<0.01).ECG chan- ges improved in 48(84%) and in 5(45.4%) respectively (P<0.05).TxB_2 decreased from 438±179.4 to 173.7±62.93ng/ml(P<0.001),platelet aggregation decreared from 31.8% to 20.3%(P<0.01),and significantly improved than control group. The results suggested that early introduction of IV NTG and H therapy in unstable angina pectoris may be very effective to prevent AMI and relief symptoms.