冠心病患者性激素及高密度脂蛋白改变的观察

Observation on plasma sex hormones level and serum high density lipoprotein in coronary artery disease

本文测定30例冠心病人和130例健康人的血浆性激素水平、血清总胆固醇、高密度脂蛋白胆固醇及其亚组分。结果显示:男性冠心病组雌二醇水平明显高于健康人组,女性冠心病组性激素水平无明显变化。冠心病组高密度脂蛋白水平明显低于健康人组,主要为高密度脂蛋白亚组分2胆固醇下降所致。血清总胆固醇无明显改变.

The plasma sex hormones and serum total cholesterol(T-CH),high density lipoprotein cholesterol (HDL-CH) and its subclasses HDL_2-CH and HDL_3-CH were examined in 30 patients with coronary artery disease and 30 age-matched nor- mal controls in this study.The results showed plasma estradiol(E_2)level was significantly higher in male patients than in male controls(P<0.01).No changes were found in testosterone(T) level and E_2/T ratio(P>0.05).E_2 and T level were the same between female patients and controls while E_2/T ratio was significantly lower in patients than in normal controls(P<0.05).HDL-CH level was lower in CAD than in normal controls,mainly due to decrease of HDL_2-CH and similar changes were demonstrated in HDL-CH/T-CH and HDL_2-CH/HDL_3-CH ratio. Atherogenic index was higher in CAD than normal controls(P<0.01).