垂体瘤术后低钠血症的临床观察分析与治疗

The early clinical observation of the ailment of water and electrolyte in the patients after resection of pituitary adenoma

目的 :探讨垂体瘤术后早期低钠血症与尿崩的关系及其治疗。方法 :对 6 0例垂体瘤患者术后 2周内发生的水电解质紊乱进行观察分析与治疗。结果 :尿崩 2 8例 ,其中并低血钠 15例 ,高血钠 2例 ,正常血钠 11例 ;无尿崩 32例 ,其中并低血钠 9例 ,正常血钠 2 3例。统计分析示 :尿崩与低血钠有关 (p <0 .0 5 )。合理使用垂体后叶素和长效尿崩停的同时加强补钠 ,必要时联合应用血浆白蛋白可纠正水电解质平衡紊乱。结论 :垂体瘤术后尿崩可引起血钠浓度异常 。

Objective:To discuss the mechanism of ailment of water and electrolyte. Method: We have studied the incidence of postoperative early diabetes insipidus and hyponatremia in 60 consecutive patients after resection of pituitary adenoma. Result: Early diabetes insipidus occurred in 28 of 60 patients, hyponatremia was observed in 15 of 28 patients with early diabetes insipidus. No early diabetes insipidus was observed in 32 of 60 patients, 11 of them had hyponatremia. Conclusion: Diabetes insipidus may cause abnormality of natremiahypo (p<0.05), but not the only factor. It may be related to the inappropriate secretion of antidiuretic hormone and cerebral salt wasting.